Acta Chimica Slovaca (ACS) publishes papers on fundamental and applied aspects of chemistry, biochemistry, chemical technology, chemical engineering and process control, biotechnology and food technology. Welcome are also topics which include chemical aspects of materials, physical chemistry and chemical physics, analytical chemistry, macromolecular chemistry and biomedical engineering.

Electrochemical and analytical performance of boron-doped diamond electrode for determination of ascorbic acid

Ivana Sálusová, Kristína Cinková, Barbora Brtková, Marian Vojs a, Marián Marton b, Ľubomír Švorc *

Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, SK-812 37 Bratislava, Slovak Republic
a Institute of Electronics and Photonics, Faculty of Electrical Engineering and Information Technology, Slovak University of Technology in Bratislava, Ilkovičova 3, SK-812 19 Bratislava, Slovak Republic
b Institute of Electronics and Photonics, Faculty of Electrical Engineering and Information Technology, Slovak University of Technology in Bratislava, Ilkovičova 3, SK-812 19 Bratislava, Slovak Republic

E-mail: * lubomir.svorc@stuba.sk

Abstract: The electrochemical behavior and determination of ascorbic acid (AA) was investigated at a bare boron-doped diamond (BDD) electrode using cyclic and differential pulse voltammetry. The influence of pH of supporting electrolyte and scan rate on the current response of analyte was examined to select the suitable experimental conditions. It was found that AA provided one well-shaped irreversible and diffusion-controlled oxidation peak at +0.87 V vs. Ag/AgCl in Britton-Robinson buffer pH 4.0. Applying differential pulse voltammetry, the peak current of AA was in the linearly proportional to its concentration from 5 × 10–6 to 2 × 10–4 mol L–1 (R2 = 0.999), with the limit of detection of 1.1 × 10–6 mol L–1 and the good repeatability (relative standard deviation of 2.3 %). The developed electroanalytical protocol was successfully applied to determine the content of AA in commercial pharmaceutical preparations, based on the standard additions method, with the obtained recovery of 122 %. The accomplished analytical performance indicates that BDD electrodes are promising electrochemical sensors for pharmaceutical analysis.

Keywords: ascorbic acid, boron-doped diamond, differential pulse voltammetry, limit of detection, pharmaceutical analysis

Full paper in Portable Document Format: acs_0266.pdf

Acta Chimica Slovaca, Vol. 10, No. 1, 2017, pp. 21—28, DOI: 10.1515/acs-2017-0004