Acta Chimica Slovaca (ACS) publishes papers on fundamental and applied aspects of chemistry, biochemistry, chemical technology, chemical engineering and process control, biotechnology and food technology. Welcome are also topics which include chemical aspects of materials, physical chemistry and chemical physics, analytical chemistry, macromolecular chemistry and biomedical engineering.

Photocytotoxicity of [Cu(N-salicyliden-L-glutamato · 2H2O] · isoquinoline

Jana Pisarčíková, Lýdia Čižeková, Helena Paulíková, Zuzana Vantová * a

Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovak Republic
a Department of Chemical and Biochemical Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovak Republic

E-mail: * zuzana.vantova@gmail.com

Abstract: The metal complexes have a significant role in photodynamic therapy (PDT). The most common metals studied for PDT of tumors are transitional metals. In this paper we have studied the copper(II) complexes of N-salicyliden-L-glutamate. The photocytostatic effect was monitored against mouse leukemic cell line L1210. Photocytostatic effect was confirmed for [Cu(N-salicyliden-L-glutamato·2H2O]·isoquinoline (CuCIQ), but it wasn’t observed for the parental molecule [Cu(N-salicyliden-L-glutamato·2H2O]·H2O. CuCIQ had photocytotoxic effect already at 10 mM concentration. Irradiated cells (1050 mJ.cm–2, l = 365 nm) had half the viability of the cells incubated with CuCIQ in the dark (72 h). Co-incubation of the cells with CuCIQ and ascorbic acid increased this photocytotoxic effect and this effect correlated with the elevated level of lipoperoxidation.

Keywords: photodynamic therapy, photosensitizers, metal complexes, ascorbic acid

Full paper in Portable Document Format: acs_0145.pdf

Acta Chimica Slovaca, Vol. 6, No. 1, 2013, pp. 55—59, DOI: 10.2478/acs-2013-0010