Acta Chimica Slovaca (ACS) publishes papers on fundamental and applied aspects of chemistry, biochemistry, chemical technology, chemical engineering and process control, biotechnology and food technology. Welcome are also topics which include chemical aspects of materials, physical chemistry and chemical physics, analytical chemistry, macromolecular chemistry and biomedical engineering.

Intracellular Changes of GABA metabolism in Trichoderma viride and other fungi with age and carbon source

Michal Kaliňák *, Tibor Liptaj, Nadežda Prónayová a, Ľudovít Varečka b

Institute of Biochemistry, Nutrition and Health Protection, Faculty of Chemical and Food Technology, STU, Radlinského 9, 812 37 Bratislava, Slovakia
a Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, STU, Radlinského 9, 812 37 Bratislava, Slovakia
b Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, STU, Radlinského 9, 812 37 Bratislava, Slovakia

E-mail: * michal.kalinak@stuba.sk

Abstract: The concentration of γ-aminobutyric acid (GABA) in extracts of Trichoderma viride grown on sucrose decreased in an age-dependent manner. GABA also disappeared from mycelium when fungus was transferred to the medium with non-saccharide substrate (citrate). Comparative studies with mycelia of Penicillium simplicissimum and Aspergillus nidulans demonstrated similar development of GABA levels during the cultivation. However, in yeast Saccharomyces cerevisiae the amount of GABA was undetectable under aerobic conditions. Results show that GABA shunt is not only active in filamentous fungi but that it seems to be developmentally regulated.

Keywords: filamentous fungi, metabolites, GABA, development, aging

Full paper in Portable Document Format: acs_0012.pdf

Acta Chimica Slovaca, Vol. 1, No. 1, 2008, pp. 134—142